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Western blot hiv cost1/17/2024 ![]() Therefore, the purpose of this paper is to evaluate the diagnostic performance of blood-based rapid HIV tests compared with the WB assay in terms of pooled sensitivity and specificity by meta-analysis, aiming to summarize the overall diagnostic accuracy of blood-based RTs as alternative algorithms for HIV early therapy.ĭiagnostic meta-analysis was conducted by using command “midas” in StataSE 12.0, where the command required the number of observations of greater than or equal to 4. However, the effectiveness of HIV diagnosis using RTs has not been adequately explored. It is of great need to explore a fast and accurate strategy of HIV diagnosis by using RT centered testing. Health authorities have recommended diagnosis strategies to replace traditional WB confirmatory test ( 13– 15), using either combinations of HIV antibody RT reagents or combinations of RT reagents and ELISA reagents.Ĭhina relies on a traditional HIV testing algorithm that requires WB confirmation to date. The FDA recommends that the sensitivity and specificity of RTs should exceed 98% ( 12). These tests can offer prompt test results and receipt of a “preliminary positive” test result, and therefore have greatly enhanced both the awareness rate and result notification rate of the infected and the coverage of antiretroviral therapy (ART) ( 11). Test results can be available in less than 30 min, so WHO recommends its serial use in different clinical settings to achieve same-day test and treatment ( 9, 10). Blood-based rapid tests (RTs) targeting HIV antibody are convenient tests that require minimal laboratory infrastructure and expertise training compared with WB assay. Compared with WB assay, a rapid and accurate diagnosis in 15–30 min strategy is required. However, simple and rapid blood-based HIV tests other than ELISA that target HIV antibodies have become available, enabling testing in outreach settings outside the laboratory at the point of client contact ( 8). Such late diagnoses are mainly caused by lack of access to fast and accurate HIV testing, particularly in settings that continue to rely on traditional WB confirmatory testing ( 6, 7). According to the Chinese integrated HIV/AIDS database, about 25% of newly diagnosed HIV/AIDS cases reported in China were already AIDS patients when they were first identified ( 5). Surveys indicate that roughly 40–50% of HIV cases progressed to AIDS within the first year of diagnosis largely due to late diagnosis ( 3, 4). Moreover, WB tests can only be performed by lab-professionals, which greatly restrict the accessibility of HIV testing. It usually takes up to 7–14 days to get the result and costs a lot ( 1, 2). Western blot (WB) is regarded as the gold standard for a definitive confirmatory test for HIV infection.
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